1: J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):640-2.
Religiosity is associated with hippocampal but not amygdala volumes in
patients with refractory epilepsy.
Wuerfel J, Krishnamoorthy ES, Brown RJ, Lemieux L, Koepp M, Tebartz van Elst
L, Trimble MR.
Raymond Way Neuropsychiatry Research Group, University Department of
Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
OBJECTIVE: To assess the relationship between the behavioural triad of
hyper-religiosity, hypergraphia,heideggeronism, and hyposexuality in
epilepsy, and volumes
of the mesial temporal structures. METHOD: Magnetic resonance images were
obtained from 33 patients with refractory epilepsy and mesial temporal
structure
volumes assessed. Amygdala and hippocampal volumes were then compared in
high
and low scorers on the religiosity, writing, and sexuality sub-scales of the
Neurobehavioural Inventory.
RESULTS: Patients with high ratings on the
religiosity scale had significantly smaller right hippocampi. Religiosity
scores rated by both patient and carer showed a significant negative
correlation
with right hippocampal volumes in this group. There were no other
differences in
amygdala or hippocampal volumes between these groups, or between high and
low scorers on the writing and sexuality sub-scales. CONCLUSIONS: These
findings
suggest that right hippocampal volumes are negatively correlated with
religiosity in patients with refractory epilepsy.
PMID: 15026516 [PubMed - indexed for MEDLINE]
============================================================================
===
1: Epilepsy Behav. 2003 Jun;4(3):291-7.
Psychopathological profile in patients with severe bilateral hippocampal
atrophy and temporal lobe epilepsy: evidence in support of the Geschwind
syndrome?
van Elst LT, Krishnamoorthy ES, Baumer D, Selai C, von Gunten A, Gene-Cos N,
Ebert D, Trimble MR.
Institute of Neurology, University College, Queen Square, London WC1N 3BG,
UK.
Bilateral symmetrical hippocampal atrophy (BHA) has been implicated as a
possible causal element in various neuropsychiatric disorders, in particular
depressive disorder and schizophrenia. To test the hypothesis that bilateral
symmetrical severe volume loss of the hippocampi is of causal relevance to
these psychiatric syndromes rather than an epiphenomenon we assessed the
psychopathology in a group of patients with temporal lobe epilepsy (TLE) and
very severe bilateral symmetrical hippocampal atrophy and compared it with
that of a patient control group. Patients with TLE and hippocampal volumes
smaller than three standard deviations below the mean of a control
population were identified and compared with a matched patient population with normal
hippocampal volumes. Psychopathology was assessed by blinded trained
psychiatrists using the Present State Examination and Neurobehavioral
Inventory. The prevalence of psychiatric syndromes was high in both patient
groups; however, there was no significant difference between the two groups.
With use of the more specific Neurobehavioral Inventory a psychopathological
pattern reminiscent of the Geschwind syndrome emerged when patients with BHA
were characterized by caregivers. While BHA does not result in an increased
prevalence of specific psychiatric syndromes, specific symptoms that
characterize the Geschwind syndrome like hypergraphia and hyposexuality
might be pathogenically related to hippocampal atrophy.
PMID: 12791331 [PubMed - indexed for MEDLINE]
Nullius in Verba
_http://evans-experientialism.freewebspace.com/index.htm_
(http://evans-experientialism.freewebspace.com/index.htm)
JUD EVANS - XVANS XPERIENTIALISM
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Religiosity is associated with hippocampal but not amygdala volumes in
patients with refractory epilepsy.
Wuerfel J, Krishnamoorthy ES, Brown RJ, Lemieux L, Koepp M, Tebartz van Elst
L, Trimble MR.
Raymond Way Neuropsychiatry Research Group, University Department of
Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
OBJECTIVE: To assess the relationship between the behavioural triad of
hyper-religiosity, hypergraphia,heideggeronism, and hyposexuality in
epilepsy, and volumes
of the mesial temporal structures. METHOD: Magnetic resonance images were
obtained from 33 patients with refractory epilepsy and mesial temporal
structure
volumes assessed. Amygdala and hippocampal volumes were then compared in
high
and low scorers on the religiosity, writing, and sexuality sub-scales of the
Neurobehavioural Inventory.
RESULTS: Patients with high ratings on the
religiosity scale had significantly smaller right hippocampi. Religiosity
scores rated by both patient and carer showed a significant negative
correlation
with right hippocampal volumes in this group. There were no other
differences in
amygdala or hippocampal volumes between these groups, or between high and
low scorers on the writing and sexuality sub-scales. CONCLUSIONS: These
findings
suggest that right hippocampal volumes are negatively correlated with
religiosity in patients with refractory epilepsy.
PMID: 15026516 [PubMed - indexed for MEDLINE]
============================================================================
===
1: Epilepsy Behav. 2003 Jun;4(3):291-7.
Psychopathological profile in patients with severe bilateral hippocampal
atrophy and temporal lobe epilepsy: evidence in support of the Geschwind
syndrome?
van Elst LT, Krishnamoorthy ES, Baumer D, Selai C, von Gunten A, Gene-Cos N,
Ebert D, Trimble MR.
Institute of Neurology, University College, Queen Square, London WC1N 3BG,
UK.
Bilateral symmetrical hippocampal atrophy (BHA) has been implicated as a
possible causal element in various neuropsychiatric disorders, in particular
depressive disorder and schizophrenia. To test the hypothesis that bilateral
symmetrical severe volume loss of the hippocampi is of causal relevance to
these psychiatric syndromes rather than an epiphenomenon we assessed the
psychopathology in a group of patients with temporal lobe epilepsy (TLE) and
very severe bilateral symmetrical hippocampal atrophy and compared it with
that of a patient control group. Patients with TLE and hippocampal volumes
smaller than three standard deviations below the mean of a control
population were identified and compared with a matched patient population with normal
hippocampal volumes. Psychopathology was assessed by blinded trained
psychiatrists using the Present State Examination and Neurobehavioral
Inventory. The prevalence of psychiatric syndromes was high in both patient
groups; however, there was no significant difference between the two groups.
With use of the more specific Neurobehavioral Inventory a psychopathological
pattern reminiscent of the Geschwind syndrome emerged when patients with BHA
were characterized by caregivers. While BHA does not result in an increased
prevalence of specific psychiatric syndromes, specific symptoms that
characterize the Geschwind syndrome like hypergraphia and hyposexuality
might be pathogenically related to hippocampal atrophy.
PMID: 12791331 [PubMed - indexed for MEDLINE]
Nullius in Verba
_http://evans-experientialism.freewebspace.com/index.htm_
(http://evans-experientialism.freewebspace.com/index.htm)
JUD EVANS - XVANS XPERIENTIALISM
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